PR002800 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8QV7P

Description:Neuronal NAD⁺ depletion via NMNAT2 loss reprograms brain metabolism toward fatty-acid oxidation, lipid depletion, and oxidative stress. Multi-omics profiling (untargeted metabolomics and lipidomics) of NMNAT2 conditional knockout and SARM1-deleted mouse cortex revealed coordinated changes in glycolysis, redox cofactors, and lipid pathways. Complete SARM1 deletion restored metabolic and lipid balance, supporting the NMNAT2–SARM1 axis as a key regulator of neuronal and glial metabolism.

Results found

Linked to

	Label	Description
	SA523855 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523866 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523863 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523870 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523861 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	ST004432 Rawfiles.zip File (Entity type)	A 4.73 GB file from Metabolomics produced from OBI:0003097 as part of the PR002800 project
	SU004593 Subject (Entity type)	A subject produced as part of the PR002800 project
	SA523849 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523857 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project
	SA523858 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002800 project

SA523855

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523866

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523863

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523870

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523861

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

ST004432 Rawfiles.zip

File (Entity type)

A 4.73 GB file from Metabolomics produced from OBI:0003097 as part of the PR002800 project

SU004593

Subject (Entity type)

A subject produced as part of the PR002800 project

SA523849

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523857

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

SA523858

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002800 project

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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