PR001359 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8270X

Description:Despite recent advances, diabetic nephropathy (DN) remains a major public health concern. The precise underlying molecular mechanisms of DN remain elusive. Accumulating recent evidence suggests that mitochondrial integrity and lipid metabolism in podocytes significantly contribute to the pathogenesis of DN. However, the interplay between these two key metabolic regulators of DN is not fully understood. This study examines the role of ChREBP (carbohydrate-response element-binding protein), a master regulator of lipogenesis, on mitochondrial morphology and progression of DN. Our findings suggest that diabetic mice with podocyte-specific deletion of ChREBP are protected against mitochondrial fragmentation and progression of DN. Using liquid chromatography coupled with mass spectrometry, we identified the central role of ChREBP-induced plasmalogen phospholipids in linking mitochondrial lipidomes with mitochondrial dynamics in DN.

Results found

Linked to

	Label	Description
	SA205785 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205778 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205779 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205780 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	ST002145 ChREBP raw data.zip File (Entity type)	A 1.47 GB file from Metabolomics produced from OBI:0003097 as part of the PR001359 project
	SU002230 Subject (Entity type)	A subject produced as part of the PR001359 project
	SA205786 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205787 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205782 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project
	SA205783 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001359 project

SA205785

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205778

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205779

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205780

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

ST002145 ChREBP raw data.zip

File (Entity type)

A 1.47 GB file from Metabolomics produced from OBI:0003097 as part of the PR001359 project

SU002230

Subject (Entity type)

A subject produced as part of the PR001359 project

SA205786

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205787

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205782

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

SA205783

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001359 project

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.