LTB (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:4050, HGNC:6711, LTB, MIM:600978, NM_002341, NM_009588, NP_002332, NP_033666, TNFC, TNFSF3, TNLG1C, lymphotoxin beta, p33

Id:ENSG00000231314

Description:lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711]

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LTB's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LTB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LTB.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LTB.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LTB.

Results found

Linked to

	Label	Description
	Visual loss Phenotype (Entity type)	Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise t...
	Autism Phenotype (Entity type)	Autism is a neurodevelopmental disorder characterized by impaired social interaction and communicati...
	Anxiety Phenotype (Entity type)	Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses...
	Allergy Phenotype (Entity type)	An allergy is an immune response or reaction to substances that are usually not harmful.
	Depression Phenotype (Entity type)	Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...
	Obesity Phenotype (Entity type)	Accumulation of substantial excess body fat.
	Hypospadias Phenotype (Entity type)	Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displa...

Visual loss

Phenotype (Entity type)

Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise t...

Autism

Phenotype (Entity type)

Autism is a neurodevelopmental disorder characterized by impaired social interaction and communicati...

Anxiety

Phenotype (Entity type)

Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses...

Allergy

Phenotype (Entity type)

An allergy is an immune response or reaction to substances that are usually not harmful.

Depression

Phenotype (Entity type)

Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover fr...

Obesity

Phenotype (Entity type)

Accumulation of substantial excess body fat.

Hypospadias

Phenotype (Entity type)

Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displa...

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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