H4C16 (Gene)

Entrez:121504

Ensembl:ENSG00000197837

Description:H4 histone 16

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View H4C16's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with H4C16.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using H4C16.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for H4C16.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with H4C16.

Results found

Linked to

	Label	Description
	GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE128885 deferiprone macrophage 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE225901 dexamethasone 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE203329 HCC knockout 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 pyridoxine 7 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE173201 cisplatin 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE258991 enzalutamide DK1 [Tursiops] 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE239844 crizotinib 4 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE164529 tamoxifen 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE133087 metformin 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE128885 deferiprone macrophage 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE225901 dexamethasone 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE203329 HCC knockout 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 pyridoxine 7 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE173201 cisplatin 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE258991 enzalutamide DK1 [Tursiops] 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE239844 crizotinib 4 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE164529 tamoxifen 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE133087 metformin 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.