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CLCN1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CLC1, CLCN1, ENTREZ:1180, HGNC:2019, MIM:118425, NM_000083, NP_000074, NR_046453, XM_011515782, XM_017011739, XM_017011740, XP_011514084, XP_016867228, XP_016867229, chloride voltage-gated channel 1
Id:ENSG00000188037
Entrez:1180
Ensembl:ENSG00000188037
Description:chloride voltage-gated channel 1
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CLCN1's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CLCN1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CLCN1.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CLCN1.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CLCN1.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE193351 ruxolitinib 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE185519 3 V 5 GILTERITINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE165071,GSE165072 1 V 0 DEXAMETHASONE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE186709 GSE186711 MLL inhibition 4 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE157904 3 V 1 DOXORUBICIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213611 NUF2 knockdown OVCAR-3 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE110709 GSK-J4 5 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE193351 1 V 2 RUXOLITINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE186709 GSE186711 MLL inhibition 3 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE193351 ruxolitinib 1 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE185519 3 V 5 GILTERITINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE165071,GSE165072 1 V 0 DEXAMETHASONE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE186709 GSE186711 MLL inhibition 4 v 6 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE157904 3 V 1 DOXORUBICIN MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213611 NUF2 knockdown OVCAR-3 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE110709 GSK-J4 5 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193351 1 V 2 RUXOLITINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE186709 GSE186711 MLL inhibition 3 v 6 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.