NRG3 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:10718, HGNC:7999, HRG3, MIM:605533, NM_001010848, NM_001165972, NM_001165973, NM_001370081, NM_001370082, NM_001370083, NM_001370084, NP_001010848, NP_001159444, NP_001159445, NP_001357010, NP_001357011, NP_001357012, NP_001357013, NRG3, NR_163251, NR_163252, NR_163253, XM_011539172, XM_011539173, XM_011539175, XM_011539178, XM_017015573, XM_017015574, XM_017015575, XM_017015576, XM_017015577, XM_017015578, XM_017015579, XM_017015580, XM_017015582, XM_017015583, XM_017015584, XM_024447781, XP_011537474, XP_011537475, XP_011537477, XP_011537480, XP_016871062, XP_016871063, XP_016871064, XP_016871065, XP_016871066, XP_016871067, XP_016871068, XP_016871069, XP_016871071, XP_016871072, XP_016871073, XP_024303549, XR_001747009, neuregulin 3, pro-NRG3

Omim:OMIM:605533

Nci:C26550

Id:ENSG00000185737

Hgnc:HGNC:7999

Entrez:10718

Ensembl:ENSG00000185737

Description:neuregulin 3

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View NRG3's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with NRG3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using NRG3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for NRG3.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with NRG3.

Results found

Linked to

	Label	Description
	GSE135350 2 V 4 DEXAMETHASONE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 etoposide leukocyte 6 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 8 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 4 V 1 ETOPOSIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE220097 4 V 1 ENZALUTAMIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 10 V 6 TRAMETINIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE130437 0 V 1 PALBOCICLIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE151612 4 V 2 PRACINOSTAT HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE216540 fulvestrant 10 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE109285 5 V 2 GLUCAGON MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE135350 2 V 4 DEXAMETHASONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 etoposide leukocyte 6 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 8 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 4 V 1 ETOPOSIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE220097 4 V 1 ENZALUTAMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 10 V 6 TRAMETINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE130437 0 V 1 PALBOCICLIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE151612 4 V 2 PRACINOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE216540 fulvestrant 10 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE109285 5 V 2 GLUCAGON MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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