NEU1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:4758, HGNC:7758, MIM:608272, NANH, NEU, NEU1, NM_000434, NP_000425, SIAL1, neuraminidase 1

Id:ENSG00000184494

Description:neuraminidase 1 [Source:HGNC Symbol;Acc:HGNC:7758]

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View NEU1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with NEU1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using NEU1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for NEU1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with NEU1.

Results found

Linked to

	Label	Description
	Visual loss Phenotype (Entity type)	Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise t...
	TARGET ID 20058 Collection (Entity type)	TargetPage Collection: (TID:20058; NCBI_GENE_ID:, FILE=tcrd_target_20058.json)
	NEU1 associations Collection (Entity type)	Associations for NEU1_associations
	Retinopathy Phenotype (Entity type)	Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wid...
	Atherosclerosis Phenotype (Entity type)	A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls ...

Visual loss

Phenotype (Entity type)

Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise t...

TARGET ID 20058

Collection (Entity type)

TargetPage Collection: (TID:20058; NCBI_GENE_ID:, FILE=tcrd_target_20058.json)

NEU1 associations

Collection (Entity type)

Associations for NEU1_associations

Retinopathy

Phenotype (Entity type)

Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wid...

Atherosclerosis

Phenotype (Entity type)

A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls ...

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CFDE Workbench

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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