EWSR1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:2130, EWS RNA binding protein 1, EWS, EWS-FLI1, EWSR1, HGNC:3508, MIM:133450, NM_001163285, NM_001163286, NM_001163287, NM_005243, NM_013986, NP_001156757, NP_001156758, NP_001156759, NP_005234, NP_053733, XM_005261389, XM_005261390, XM_011529995, XM_011529996, XM_011529997, XM_011529998, XM_011529999, XM_011530000, XM_011530001, XM_011530002, XM_017028644, XM_017028645, XM_017028646, XM_017028647, XM_017028648, XM_017028649, XM_017028650, XM_017028651, XM_017028652, XM_017028653, XM_017028654, XM_017028655, XM_017028656, XM_017028657, XM_017028658, XM_017028659, XM_017028660, XM_017028661, XM_017028662, XM_017028663, XM_017028664, XM_017028665, XM_017028666, XM_024452180, XM_024452181, XP_005261446, XP_005261447, XP_011528297, XP_011528298, XP_011528299, XP_011528300, XP_011528301, XP_011528302, XP_011528303, XP_011528304, XP_016884133, XP_016884134, XP_016884135, XP_016884136, XP_016884137, XP_016884138, XP_016884139, XP_016884140, XP_016884141, XP_016884142, XP_016884143, XP_016884144, XP_016884145, XP_016884146, XP_016884147, XP_016884148, XP_016884149, XP_016884150, XP_016884151, XP_016884152, XP_016884153, XP_016884154, XP_016884155, XP_024307948, XP_024307949, XR_002958676, bK984G1.4

Omim:OMIM:133450

Id:a70c7683-6692-5d05-b95a-ae508e0058b3

Hgnc:HGNC:3508

Entrez:2130

Ensembl:ENSG00000182944

Description:EWS RNA binding protein 1

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View EWSR1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with EWSR1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using EWSR1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for EWSR1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with EWSR1.

Results found

Linked to

	Label	Description
	GSE150244 TRIM8 knockout 3 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 10 v 15 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE226525 GSE226527 HNRNPH2 knockout 6 v 5 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 ADIPOR2 knockout HEK293 1 v 6 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 4 V 1 ETOPOSIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE48812 sulforaphane 4 v 10 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE135030 3 V 10 FLUDARABINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE145195 PPP2R3B overexpression 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE165334 2 V 0 DABRAFENIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE242290 3 V 2 GLUTATHIONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE150244 TRIM8 knockout 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 10 v 15 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE226525 GSE226527 HNRNPH2 knockout 6 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 ADIPOR2 knockout HEK293 1 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE120612 4 V 1 ETOPOSIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE48812 sulforaphane 4 v 10 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE135030 3 V 10 FLUDARABINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE145195 PPP2R3B overexpression 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE165334 2 V 0 DABRAFENIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE242290 3 V 2 GLUTATHIONE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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