PLA2G1B (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:5319, HGNC:9030, MIM:172410, NM_000928, NP_000919, PLA2, PLA2A, PLA2G1B, PPLA2, phospholipase A2 group IB

Omim:OMIM:172410

Id:ENSG00000170890

Hgnc:HGNC:9030

Entrez:5319

Ensembl:ENSG00000170890

Description:phospholipase A2 group IB

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PLA2G1B's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PLA2G1B.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PLA2G1B.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PLA2G1B.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PLA2G1B.

Results found

Linked to

	Label	Description
	GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE109913 1 V 2 BLEOMYCIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE135352 6 V 4 NAPABUCASIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE203329 HCC knockout 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434,GSE202438 12 V 14 TALAZOPARIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE155031 catechin SH-SY5Y 6 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE155031 6 V 0 DEXTRAN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE171352 2 V 3 GLUCAGON HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE199034 1 V 2 PIRFENIDONE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE235234 2 V 3 CORTICOSTERONE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE109913 1 V 2 BLEOMYCIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE135352 6 V 4 NAPABUCASIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE203329 HCC knockout 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434,GSE202438 12 V 14 TALAZOPARIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE155031 catechin SH-SY5Y 6 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE155031 6 V 0 DEXTRAN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE171352 2 V 3 GLUCAGON HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE199034 1 V 2 PIRFENIDONE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE235234 2 V 3 CORTICOSTERONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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