DEFA5 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)

Synonyms:DEF5, DEFA5, ENTREZ:1670, HD-5, HGNC:2764, MIM:600472, NM_021010, NP_066290, defensin alpha 5

Omim:OMIM:600472

Id:ENSG00000164816

Hgnc:HGNC:2764

Entrez:1670

Ensembl:ENSG00000164816

Description:defensin alpha 5

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DEFA5's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DEFA5.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DEFA5.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DEFA5.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DEFA5.

Results found

Linked to

	Label	Description
	GSE143782 calcitriol 3 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE143782 3 V 11 CALCITRIOL HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE143782 calcitriol 7 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE143782 7 V 11 CALCITRIOL HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GPR160 IDG GPCR ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	ADGRG7 IDG GPCR ARCHS4 coexpression Gene Set (Entity type)	A Gene Set from IDG
	ATP5F1 Down Gene Set (Entity type)	A Gene Set from LINCS
	DDR2 Down Gene Set (Entity type)	A Gene Set from LINCS
	PTPN4 Down Gene Set (Entity type)	A Gene Set from LINCS
	Ethionamide Down Gene Set (Entity type)	A Gene Set from LINCS

GSE143782 calcitriol 3 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE143782 3 V 11 CALCITRIOL HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE143782 calcitriol 7 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE143782 7 V 11 CALCITRIOL HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GPR160 IDG GPCR ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

ADGRG7 IDG GPCR ARCHS4 coexpression

Gene Set (Entity type)

A Gene Set from IDG

ATP5F1 Down

Gene Set (Entity type)

A Gene Set from LINCS

DDR2 Down

Gene Set (Entity type)

A Gene Set from LINCS

PTPN4 Down

Gene Set (Entity type)

A Gene Set from LINCS

Ethionamide Down

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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