Synonyms:BDPLT21, ENTREZ:2313, EWSR2, FLI1, Fli-1 proto-oncogene, ETS transcription factor, HGNC:3749, MIM:193067, NM_001167681, NM_001271010, NM_001271012, NM_002017, NP_001161153, NP_001257939, NP_001257941, NP_002008, SIC-1, XM_011542701, XM_011542702, XM_017017405, XM_017017406, XP_011541003, XP_011541004, XP_016872894, XP_016872895
Id:ENSG00000151702
Description:Fli-1 proto-oncogene, ETS transcription factor
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]