MSTN (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:2660, GDF8, HGNC:4223, MIM:601788, MSLHP, MSTN, NM_005259, NP_005250, myostatin

Id:ENSG00000138379

Entrez:2660

Description:myostatin

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MSTN's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MSTN.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MSTN.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MSTN.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MSTN.

Results found

Linked to

	Label	Description
	GSE147876,GSE147877 2 V 7 ENZALUTAMIDE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE119007 prostaglandin TS-A clone E2 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE77108 saha 6 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE171837 3 V 1 BORTEZOMIB MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 4 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE152699 GSE152723 vemurafenib 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE164874 prednisolone muscle organ 5 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE77108 6 V 2 SAHA HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680,GSE182683 5 V 13 DEXAMETHASONE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE222676 ABCA1 knockout IMR-90 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE147876,GSE147877 2 V 7 ENZALUTAMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE119007 prostaglandin TS-A clone E2 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE77108 saha 6 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE171837 3 V 1 BORTEZOMIB MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE147876 GSE147877 enzalutamide MR42D 4 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE152699 GSE152723 vemurafenib 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE164874 prednisolone muscle organ 5 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE77108 6 V 2 SAHA HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680,GSE182683 5 V 13 DEXAMETHASONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE222676 ABCA1 knockout IMR-90 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

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CFDE Workbench

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Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.