APOBEC3A (Gene)

Organism:

Homo sapiens

Synonyms:A3A, APOBEC3A and APOBEC3B deletion hybrid, APOBEC3A, APOBEC3A_B, ARP3, ENTREZ:100913187, ENTREZ:200315, HGNC:17343, HGNC:44196, MIM:607109, NM_001193289, NM_001270406, NM_145699, NP_001180218, NP_001257335, NP_663745, PHRBN, apolipoprotein B mRNA editing enzyme catalytic subunit 3A, bK150C2.1

Omim:OMIM:607109

Id:ENSG00000128383

Hgnc:HGNC:17343

Entrez:200315

Ensembl:ENSG00000128383

Description:apolipoprotein B mRNA editing enzyme catalytic subunit 3A

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View APOBEC3A's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with APOBEC3A.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using APOBEC3A.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for APOBEC3A.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with APOBEC3A.

Results found

Linked to

	Label	Description
	GSE82032 trametinib HCC1143 3 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE97616 GSE97617 NOK overexpression HEK RNA Small Interfering 7 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE212312 FBXW7 knockout Reh 1 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE233679 nicotinamide 14 v 15 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE140441 temozolomide stem cell 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE128885 deferiprone macrophage 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE97616 GSE97617 NOK overexpression HEK RNA Small Interfering 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE193900 GSE193905 PURA knockdown HeLa 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE209698 calcitriol D 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE220806 progesterone fibroblast 0 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE82032 trametinib HCC1143 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE97616 GSE97617 NOK overexpression HEK RNA Small Interfering 7 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE212312 FBXW7 knockout Reh 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE233679 nicotinamide 14 v 15 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE140441 temozolomide stem cell 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE128885 deferiprone macrophage 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE97616 GSE97617 NOK overexpression HEK RNA Small Interfering 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE193900 GSE193905 PURA knockdown HeLa 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE209698 calcitriol D 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE220806 progesterone fibroblast 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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