NR2C1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:7181, HGNC:7971, MIM:601529, NM_001032287, NM_001127362, NM_003297, NP_001027458, NP_001120834, NP_003288, NR2C1, TR2, XM_005269133, XM_006719584, XM_006719585, XM_011538716, XM_011538717, XP_005269190, XP_006719647, XP_006719648, XP_011537018, XP_011537019, XR_001748861, XR_001748862, XR_001748863, XR_001748864, XR_245956, XR_429114, XR_944699, XR_944700, nuclear receptor subfamily 2 group C member 1

Omim:OMIM:601529

Id:204dc483-1428-572a-a070-018ba5b75e15

Hgnc:HGNC:7971

Entrez:7181

Ensembl:ENSG00000120798

Description:nuclear receptor subfamily 2 group C member 1

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View NR2C1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with NR2C1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using NR2C1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for NR2C1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with NR2C1.

Results found

Linked to

	Label	Description
	GSE48812 11 V 6 SULFORAPHANE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE159678 4 V 2 CHLOROQUINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE108464 AZ-628 1 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 8 V 1 AZACITIDINE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE218378 PBX1 overexpression HCT 116 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 3 v 11 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE172219 adenosine 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE74490 0 V 1 TRIPTOLIDE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE95077 amiloride 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE207514,GSE207515 2 V 3 ACETYLCYSTEINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

GSE48812 11 V 6 SULFORAPHANE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE159678 4 V 2 CHLOROQUINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE108464 AZ-628 1 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 8 V 1 AZACITIDINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE218378 PBX1 overexpression HCT 116 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 3 v 11 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE172219 adenosine 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE74490 0 V 1 TRIPTOLIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE95077 amiloride 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE207514,GSE207515 2 V 3 ACETYLCYSTEINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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