HYAL1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:3373, HGNC:5320, HYAL-1, HYAL1, LUCA1, MIM:607071, MPS9, NAT6, NM_033159, NM_153281, NM_153282, NM_153283, NM_153284, NM_153285, NM_153286, NP_149349, NP_695013, NP_695014, NP_695015, NP_695017, NR_047690, XM_011533667, XM_011533668, XM_011533669, XP_011531969, XP_011531970, XP_011531971, hyaluronidase 1

Omim:OMIM:607071

Id:ENSG00000114378

Hgnc:HGNC:5320

Entrez:3373

Ensembl:ENSG00000114378

Description:hyaluronidase 1

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HYAL1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with HYAL1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HYAL1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HYAL1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HYAL1.

Results found

Linked to

	Label	Description
	GSE239844 crizotinib 6 v 9 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE168596 2 V 3 ADIPONECTIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE208350 H-7 Huh-7 JHH-7 0 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE241036 0 V 1 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE125157 1 V 0 PICEATANNOL MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE166315 1 V 0 DOCETAXEL MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE108464 AZ-628 6 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE207410 GSE207411 ARID1A knockdown 1 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE138937 Rad21 CTCF knockdown SLK 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE241036 0 V 3 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE239844 crizotinib 6 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE168596 2 V 3 ADIPONECTIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE208350 H-7 Huh-7 JHH-7 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE241036 0 V 1 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE125157 1 V 0 PICEATANNOL MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE166315 1 V 0 DOCETAXEL MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE108464 AZ-628 6 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE207410 GSE207411 ARID1A knockdown 1 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE138937 Rad21 CTCF knockdown SLK 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE241036 0 V 3 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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