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XRN1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:5'-3' exoribonuclease 1, ENTREZ:54464, HGNC:30654, MIM:607994, NM_001042604, NM_001282857, NM_001282859, NM_019001, NP_001269786, NP_001269788, NP_061874, SEP1, XM_006713673, XM_011512919, XM_011512920, XM_011512922, XM_017006640, XM_017006641, XM_017006642, XP_006713736, XP_011511221, XP_011511222, XP_011511224, XP_016862129, XP_016862130, XP_016862131, XRN1, XR_001740178
Omim:OMIM:607994
Id:ENSG00000114127
Hgnc:HGNC:30654
Entrez:54464
Ensembl:ENSG00000114127
Description:5'-3' exoribonuclease 1
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View XRN1's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with XRN1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using XRN1.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for XRN1.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with XRN1.

Results found

Linked to

 

Label

Description

 

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GSE171692 FXN knockdown 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

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GSE172219 adenosine 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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GSE212312 FBXW7 knockout Reh 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE140322 imatinib K-562 C.M.L. 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE140322 SRSF1 overexpression K-562 C.M.L. Imatinib 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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GSE158632 quinoline HT-29 Caco-2 3 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

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GSE155031 catechin SH-SY5Y 5 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE133933 fibulin-3 knockdown 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE150244 TRIM8 knockout 3 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE120370 0 V 6 THROMBIN MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE171692 FXN knockdown 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE172219 adenosine 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE212312 FBXW7 knockout Reh 1 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE140322 imatinib K-562 C.M.L. 3 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE140322 SRSF1 overexpression K-562 C.M.L. Imatinib 3 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE158632 quinoline HT-29 Caco-2 3 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE155031 catechin SH-SY5Y 5 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE133933 fibulin-3 knockdown 0 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.