Synonyms:CALC, CBARA1, EFHA3, ENTREZ:10367, HGNC:1530, MICU1, MIM:605084, MPXPS, NM_001195518, NM_001195519, NM_001363513, NM_006077, NP_001182447, NP_001182448, NP_001350442, NP_006068, XM_005269386, XM_011539119, XP_005269443, XP_011537421, XR_001746993, XR_001746994, XR_945586, ara CALC, mitochondrial calcium uptake 1
Omim:OMIM:605084
Id:7e9ec985-ccf2-5ada-b825-b6cfcf6d13c9
Hgnc:HGNC:1530
Description:mitochondrial calcium uptake 1
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]