CHAT (Gene)

Organism:

Homo sapiens

Synonyms:CHAT, CHOACTASE, CMS1A, CMS1A2, CMS6, ENTREZ:1103, HGNC:1912, MIM:118490, NM_001142929, NM_001142933, NM_001142934, NM_020549, NM_020984, NM_020985, NM_020986, NP_001136401, NP_001136405, NP_001136406, NP_065574, NP_066264, NP_066265, NP_066266, choline O-acetyltransferase

Omim:OMIM:118490

Id:698ef7fe-9ee5-5ae6-b873-8e3f97230334

Hgnc:HGNC:1912

Entrez:1103

Ensembl:ENSG00000070748

Description:choline O-acetyltransferase

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CHAT's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CHAT.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CHAT.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CHAT.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CHAT.

Results found

Linked to

	Label	Description
	GSE150244 TRIM8 knockout 3 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE100148 EZH2 inhibition 10 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE172016 paclitaxel 2 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE155031 catechin SH-SY5Y 5 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE198930 prunetin AGS 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE213845 EZH2 inhibition 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE213845 EZH2 inhibition 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE249544 GSE249637 temozolomide 9 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE239844 crizotinib 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE150244 TRIM8 knockout 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE100148 EZH2 inhibition 10 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE172016 paclitaxel 2 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE155031 catechin SH-SY5Y 5 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE198930 prunetin AGS 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE213845 EZH2 inhibition 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE213845 EZH2 inhibition 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE249544 GSE249637 temozolomide 9 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE239844 crizotinib 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE265788 IDH1 inhibition RNA-Directed DNA Polymerase 9 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.