TNK2 (Gene)

Organism:

Homo sapiens

Synonyms:ACK, ACK-1, ACK1, ENTREZ:10188, HGNC:19297, MIM:606994, NM_001010938, NM_001308046, NM_001382271, NM_001382272, NM_001382273, NM_001382274, NM_001382275, NM_001386164, NM_001387707, NM_001387708, NM_001387709, NM_001387710, NM_001387711, NM_001387712, NM_001387713, NM_001387714, NM_001387715, NM_001387716, NM_001387717, NM_001387718, NM_001387719, NM_001387720, NM_001387721, NM_005781, NP_001010938, NP_001294975, NP_001369200, NP_001369201, NP_001369202, NP_001369203, NP_001369204, NP_001373093, NP_001374636, NP_001374637, NP_001374638, NP_001374639, NP_001374640, NP_001374641, NP_001374642, NP_001374643, NP_001374644, NP_001374645, NP_001374646, NP_001374647, NP_001374648, NP_001374649, NP_001374650, NP_005772, NR_170678, NR_170679, NR_170680, NR_170681, NR_170682, NR_170683, NR_170684, NR_170685, NR_170686, NR_170687, NR_170688, NR_170689, NR_170690, NR_170691, NR_170692, TNK2, XM_005269274, XM_005269275, XM_011512317, XM_011512318, XM_011512321, XM_017005509, XM_024453291, XM_024453292, XM_024453293, XM_024453294, XM_024453295, XP_005269331, XP_005269332, XP_011510619, XP_011510620, XP_011510623, XP_016860998, XP_024309059, XP_024309060, XP_024309061, XP_024309062, XP_024309063, p21cdc42Hs, tyrosine kinase non receptor 2

Omim:OMIM:606994

Id:ENSG00000061938

Hgnc:HGNC:19297

Entrez:10188

Ensembl:ENSG00000061938

Description:tyrosine kinase non receptor 2

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TNK2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TNK2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TNK2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TNK2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TNK2.

Results found

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	GSE228727 2 V 1 DAPAGLIFLOZIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE207871 NPC knockdown S18 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE110178 2 V 3 TRANYLCYPROMINE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE238213 dopamine 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE195663 cisplatin 0 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE159678 4 V 2 CHLOROQUINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE164874 5 V 10 PREDNISOLONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE184210 0 V 1 GLUCAGON MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS