PR000769 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M88T11

Description:Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. We utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS).

Results found

Linked to

	Label	Description
	SA079868 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079858 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079870 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079835 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079838 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079842 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079843 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079853 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079845 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project
	SA079855 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000769 project