Description:Mucopolysaccharidosis type III (MPS III) is an autosomal recessive neurodegenerative lysosomal storage disorder that causes progressive cognitive and physical impairment, predominantly in child/early adulthood. The median age of death is 17 years as there is no safe, effective treatment approved at present. Using faithful Drosophila and murine models of MPS III, we have characterised the metabolome in MPS IIIA and MPS IIIC flies as they age.