PR002398 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8P249

Description:The aim of this study was to investigate the relationship between gut microbiota, metabolites and scar hypertrophy using the rabbit ear hypertrophic scar model. On postoperative day 28, the rabbits were divided into scar-susceptible (group H) and scar-insusceptible (group L) groups according to macroscopic scar thickness. Using fecal microbiota transplantation (FMT), we exchanged the gut microbiota of group H and group L. Untargeted metabolomics was performed before and after FMT. We found that in the rabbit ear hypertrophic scar model, scar hypertrophy was more severe in group H and was associated with fecal microbiota and their metabolites. Gut microbiota components and key genera were transferred between group H and group L by FMT, accompanied by altered levels of key metabolites such as TCDCA (bile acid taurochenodeoxycholic acid). FMT relieved scar hypertrophy in group H and vice versa. TCDCA were decreased in group H rabbit and its relative abundance was successfully reversed by heterochronic FMT.

Results found

Linked to

	Label	Description
	SA419815 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419794 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419802 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419807 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419823 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419816 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419798 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419801 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419810 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project
	SA419820 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002398 project