PR002389 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8TR66

Description:Irisin can ameliorate postmenopausal osteoporosis (PMOP) in ovariectomized (OVX) mice by promoting osteogenesis, inhibiting adipogenesis, and regulating the bone-fat balance. Similarly, irisin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) in vitro while reducing their adipogenic differentiation. Metabolomic analysis of mouse plasma revealed that the therapeutic effects of irisin are associated with pathways such as glycerophospholipid metabolism, wherein the metabolite phosphatidylcholine (PC) plays a significant role. Irisin can upregulate the metabolism of PC in OVX mice, thereby improving OP. We further investigated the metabolic role of PC and its mechanisms. By administering PC to BMSCs, we observed its effects on BMSCs and the underlying mechanisms. It was found that PC activates the canonical Wnt/β-catenin signaling pathway, promoting the osteogenic differentiation of BMSCs while inhibiting their adipogenic differentiation.

Results found

Linked to

	Label	Description
	SA418812 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418821 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418825 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	ST003818 Rawdata.zip File (Entity type)	A 10.4 GB file from Metabolomics produced from OBI:0003097 as part of the PR002389 project
	SA418805 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418807 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418820 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418814 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418808 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project
	SA418827 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002389 project