PR000320 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8MP4W

Description:The goal of this study was to determine the effects of the neuropeptide oxytocin (OT) on metabolomic profiles, using a mouse model of autism-like behavior, the BALB/cByJ inbred strain. We have previously reported that subchronic treatment with OT can lead to persistent reversal of social deficits in BALB/cByJ and other models of autism spectrum disorder (ASD). In this study, mice were given a subchronic regimen with either vehicle or OT, and then evaluated for social approach. At the end of the study, brain and blood were collected for metabolomic analysis. In addition, fecal samples were taken at different time points during the treatment and testing regimen. The results from this project could elucidate mechanisms underlying the prosocial effects of oxytocin, and identify new targets for the development of highly specific oxytocin-related drugs.

Results found

Linked to

	Label	Description
	SA019923 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA020049 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA019903 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA020106 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA020148 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA020173 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA019927 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SA024350 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project
	SU000497 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000320 project
	SA020161 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000320 project