PR002526 (Project)

Description:Due to increasingly strict regulations on the use of bisphenol A (BPA), its structurally similar alternative, bisphenol S (BPS), has been widely used as a major substitute in many industries, including food packaging. However, recent studies have revealed that BPS may promote obesity and lead to insulin resistance, especially in the early stages of life, although its exact impact is not yet fully understood. To address these concerns, this study established a mouse model to explore the exposure of female mice to BPS during pregnancy and lactation, as well as the consumption of high-fat diets by their offspring. By evaluating the biological phenotypes related to obesity and insulin resistance in the offspring mice, multi-tissue lipidomics analysis and adipose tissue proteomics analysis were carried out. Ultimately, a correlation study was conducted by combining phenotypes, lipidomics, and proteomics to explore the risks and potential mechanisms of BPS exposure to obesity and insulin resistance.