Description:Obese mothers predispose their babies to develop metabolic disorders and obesity before they are even born. The study used a mouse model of maternal high-fat diet-induced obesity that recapitulates cardiovascular and metabolic abnormalities seen in humans born to obese mothers. to compare the metabolic characteristics of bone marrow cells in newly weaned mice. The results showed that the bone marrow of offspring born to mothers on a high-fat diet primarily used glucose through OXPHOS, and presented decreased amino acid metabolism. These metabolic changes were observed in the bone marrow of the offspring at a very young age, before any symptomatic metabolic disease was present.