PR001962 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M83X6D

Description:Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that the variable response of patients may be due to their diet. In support of this hypothesis, mice subjected to experimental autoimmune encephalomyelitis (EAE), a model of MS, did not benefit from DMF treatment when fed a lauric acid-rich (LA) diet, in contrast to normal chow (NC) or, more so, a high-fiber (HFb) diet. DMF lacked efficacy in the LA diet fed group despite similar resorption and preserved effects on plasma lipids.

Results found

Linked to

	Label	Description
	SU003274 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001962 project
	SU003275 Subject (Entity type)	A subject produced as part of the PR001962 project
	ST003156 plasma DMF diet metabolomics.7z File (Entity type)	A 5.45 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	ST003157 plasma DMF diet lipidomics.7z File (Entity type)	A 14.0 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	ST003156 Batch 1 mzml.zip File (Entity type)	A 669 MB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	ST003157 Batch 1 mzml.zip File (Entity type)	A 1.47 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	ST003156 Batch 2 mzml.zip File (Entity type)	A 652 MB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	ST003157 Batch 2 mzml.zip File (Entity type)	A 1.50 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project
	SA341591 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001962 project
	SA341571 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001962 project

SU003274

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001962 project

SU003275

Subject (Entity type)

A subject produced as part of the PR001962 project

ST003156 plasma DMF diet metabolomics.7z

File (Entity type)

A 5.45 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

ST003157 plasma DMF diet lipidomics.7z

File (Entity type)

A 14.0 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

ST003156 Batch 1 mzml.zip

File (Entity type)

A 669 MB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

ST003157 Batch 1 mzml.zip

File (Entity type)

A 1.47 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

ST003156 Batch 2 mzml.zip

File (Entity type)

A 652 MB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

ST003157 Batch 2 mzml.zip

File (Entity type)

A 1.50 GB file from Metabolomics produced from OBI:0003097 as part of the PR001962 project

SA341591

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001962 project

SA341571

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001962 project

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