PR001804 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8HX5R

Description:Glutamine is a critical amino acid that serves as an energy source, building block, and signaling molecule for both the heart tissue and the immune system. However, the role of glutamine metabolism in regulating cardiac remodeling following myocardial infarction (MI) is unknown. In this study, we show that glutamine metabolism is altered both in the remote (contractile) area and in infiltrating macrophages in the infarct area after MI in adult male mice by permanent left anterior descending artery occlusion. Using untargeted metabolomics in extracted LV macrophages, we found that metabolites related to glutamine metabolism were differentially altered at days 1, 3, and 7 after MI. Glutamine metabolism in live cells was found to be increased after MI relative to no MI controls. Gene expression in the remote area of the heart indicated a loss of glutamine metabolism. Glutamine administration improved LV function at days 1, 3, and 7, which was associated with improved contractile and metabolic gene expression.

Results found

Linked to

	Label	Description
	SA315465 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SA315475 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	ST002891 rawdata.7z File (Entity type)	A 8.46 GB file from Metabolomics produced from OBI:0003097 as part of the PR001804 project
	SA315467 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SA315472 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SA315471 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SU003004 Subject (Entity type)	A subject produced as part of the PR001804 project
	SA315466 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SA315460 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project
	SA315468 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001804 project