PR002639 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8J26T

Description:Brown fat was well known as its thermogenesis function, however, many studies started to report its endocrinology role in metabolic regulation. There are no suitable systems can be use to study the circulating batokines derived from BAT. Here, we created a BAT ablation mouse model which lost most BAT in vivo. We screened the BAT- responsive circulating lipokins using this model. In conjunction with other lipid atlases, including mice tissues, BAT explant media, BAT extracellular fluid, BAT cell media, we identified the hydroxy fatty acids as the key candidate of the BAT-derived circulating lipokins. This was further validated in the human cohort with varying BAT activities. Overall, all study uncovered a BAT-derived lipokin by multidimensional lipid atlases, this lipokin was shown to control liver bioenergetics.

Results found

Linked to

	Label	Description
	SU004344 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002639 project
	SU004336 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002639 project
	SU004343 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002639 project
	ST004192 Rawfiles.zip File (Entity type)	A 11.7 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004183 mzml.zip File (Entity type)	A 1.99 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004191 mzml.zip File (Entity type)	A 1.94 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004191 Rawfiles.zip File (Entity type)	A 10.9 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004183 Rawfiles.zip File (Entity type)	A 11.8 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004192 mzml.zip File (Entity type)	A 2.08 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project
	ST004191 AN006963 Results.txt File (Entity type)	A 592 KB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

SU004344

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002639 project

SU004336

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002639 project

SU004343

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002639 project

ST004192 Rawfiles.zip

File (Entity type)

A 11.7 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004183 mzml.zip

File (Entity type)

A 1.99 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004191 mzml.zip

File (Entity type)

A 1.94 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004191 Rawfiles.zip

File (Entity type)

A 10.9 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004183 Rawfiles.zip

File (Entity type)

A 11.8 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004192 mzml.zip

File (Entity type)

A 2.08 GB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

ST004191 AN006963 Results.txt

File (Entity type)

A 592 KB file from Metabolomics produced from OBI:0003097 as part of the PR002639 project

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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