PR002434 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M81532

Description:Intervertebral disc degeneration (IVDD) is a multifactorial disease which causes structural and biochemical changes that leads to disability. Identifying the molecular signatures in the intervertebral disc (IVD) during degeneration is crucial to understand the disease pathogenesis. The study aims to identify the metabolic alterations during IVD degeneration. Control and disease IVD tissues were collected and the metabolites were extracted from nucleus pulposus tissue (NP) using triple solvent mixture (Methanol: Acetonitrile: Methanol with 2:2:1 ratio) and profiled using UHPLC-ESI-MS/MS. Untargeted metabolomics identified 832 metabolites from control and disease samples. Differential analysis revealed alterations in amino acids and lipids predominantly.

Results found

Linked to

	Label	Description
	SU004015 Subject (Entity type)	A subject produced as part of the PR002434 project
	ST003880 IVD Untargeted RAW.zip File (Entity type)	A 45.1 GB file from Metabolomics produced from OBI:0003097 as part of the PR002434 project
	SA426666 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426686 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426678 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426660 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426685 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426667 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426676 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426654 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project

SU004015

Subject (Entity type)

A subject produced as part of the PR002434 project

ST003880 IVD Untargeted RAW.zip

File (Entity type)

A 45.1 GB file from Metabolomics produced from OBI:0003097 as part of the PR002434 project

SA426666

Biosample (Entity type)