PR002434 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M81532

Description:Intervertebral disc degeneration (IVDD) is a multifactorial disease which causes structural and biochemical changes that leads to disability. Identifying the molecular signatures in the intervertebral disc (IVD) during degeneration is crucial to understand the disease pathogenesis. The study aims to identify the metabolic alterations during IVD degeneration. Control and disease IVD tissues were collected and the metabolites were extracted from nucleus pulposus tissue (NP) using triple solvent mixture (Methanol: Acetonitrile: Methanol with 2:2:1 ratio) and profiled using UHPLC-ESI-MS/MS. Untargeted metabolomics identified 832 metabolites from control and disease samples. Differential analysis revealed alterations in amino acids and lipids predominantly.

Results found

Linked to

	Label	Description
	SA426666 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426686 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426678 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426660 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426685 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426667 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426676 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426654 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426674 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project
	SA426703 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002434 project