PR002340 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M85C1M

Description:Thymoma is a rare malignant thymic epithelial tumor (TET) with an incidence of about 2 to 4 per million. In this study, we performed nontargeted lipidomic profiling study of tissue samples from 39 patients with thymoma and thymic hyperplasia using UPLC-HRMS. OPLS-DA classification models enabled discrimination of tumor from adjacent noncancerous tissue (ANT) and distant noncancerous tissue (DNT) samples in thymoma with good accuracy, sensitivity, and specificity using 5 discriminant compounds. The discriminant feature panels were verified by external validation sets, revealing characteristic lipid signatures associated with thymoma and showing prospects for entering the next evaluation stage of biomarker discovery for thymoma detection, giving hints to potential treatment targets for the disease.

Results found

Linked to

	Label	Description
	SA408968 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA408992 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	ST003756 thymoma 3.zip File (Entity type)	A 1.10 GB file from Metabolomics produced from OBI:0003097 as part of the PR002340 project
	SA409034 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA408967 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA408975 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA409005 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA409032 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA409018 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project
	SA409037 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002340 project