PR002675 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8W83V

Description:This study aimed to understand the impact of 2-deoxy-D-glucose (2DG) in modulating the transcriptional and metabolomic responses of T follicular helper cells (Tfh) in a lupus-prone mouse model (W.Yaa). Thus, we analyzed the metabolomes of Tfh cells purified the spleen of W.Yaa mice treated with 2DG versus untreated controls. Data demonstrated that inhibition of glycolysis via 2DG treatment profoundly reprogrammed the metabolic pathways of splenic Tfh cells. This includes the suppression of the pentose phosphate pathway, essential for autoimmune Tfh cell expansion and the activation of mitochondrial metabolism. The reprogrammed metabolism of Tfh cells was associated with the reduction of autoantibodies and autoimmune phenotype.

Results found

Linked to

	Label	Description
	SU004394 Subject (Entity type)	A subject produced as part of the PR002675 project
	SU004395 Subject (Entity type)	A subject produced as part of the PR002675 project
	ST004243 Human Tfh raw.zip File (Entity type)	A 336 MB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	ST004242 Mouse Tfh raw.zip File (Entity type)	A 1.17 GB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	ST004242 AN007061 Results.txt File (Entity type)	A 225 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	ST004243 AN007064 Results.txt File (Entity type)	A 71.2 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	ST004243 AN007063 Results.txt File (Entity type)	A 49.2 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	ST004242 AN007062 Results.txt File (Entity type)	A 216 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project
	SA490122 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002675 project
	SA490099 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002675 project

SU004394

Subject (Entity type)

A subject produced as part of the PR002675 project

SU004395

Subject (Entity type)

A subject produced as part of the PR002675 project

ST004243 Human Tfh raw.zip

File (Entity type)

A 336 MB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

ST004242 Mouse Tfh raw.zip

File (Entity type)

A 1.17 GB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

ST004242 AN007061 Results.txt

File (Entity type)

A 225 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

ST004243 AN007064 Results.txt

File (Entity type)

A 71.2 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

ST004243 AN007063 Results.txt

File (Entity type)

A 49.2 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

ST004242 AN007062 Results.txt

File (Entity type)

A 216 KB file from Metabolomics produced from OBI:0003097 as part of the PR002675 project

SA490122

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002675 project

SA490099

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR002675 project

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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