PR002076 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M88G1K

Description:With the phthalate plasticizer di-(2-ethylhexyl) phthalate (DEHP) being restricted because of its harmful health impacts, it has been replaced by alternatives such as diisononylcyclohexane-1,2-dicarboxylate (DINCH). Although recent research suggests that the main metabolite of DINCH, monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH), promotes adipocyte differentiation in vitro, in vivo studies have not shown changes in body weight, lipid metabolism, or adipogenic effects. However, these studies followed OECD guidelines, which are not specifically designed to detect potential metabolic disruptions in adipose tissue. Therefore, we conducted an in-depth in vivo study using the C57BL/6N mouse model to comprehensively evaluate the physiological and functional impacts of DINCH exposure on adipose tissue, including molecular-level effects.

Results found

Linked to

	Label	Description
	SA364365 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364327 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364298 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364219 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364231 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364475 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364319 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364489 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364404 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project
	SA364350 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002076 project