PR001297 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M82H7B

Description:The apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. Here, we developed a human myotube-based in vitro culture model of functionally mature tissue cysts. Metabolomic characterization of purified cysts reveals global changes that comprise increased levels of amino acids and decreased abundance of nucleobase- and tricarboxylic acid cycle-associated metabolites. In contrast to fast replicating tachyzoite forms of T. gondii these tissue cysts tolerate exposure to the aconitase inhibitor sodium fluoroacetate.

Results found

Linked to

	Label	Description
	SA193605 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193670 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193609 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193544 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193599 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193555 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193579 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193678 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193510 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project
	SA193654 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001297 project