PR002881 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M88C2X

Description:High-altitude populations exhibit distinct cardiovascular disease patterns compared to sea-level populations, yet the underlying mechanisms remain poorly understood. Epidemiological studies reveal that individuals living at altitudes above 2,500 meters demonstrate altered cardiovascular risk profiles. Populations with multi-generational high-altitude exposure have undergone evolutionary adaptations that affect cardiovascular physiology and disease susceptibility. This project aims to conduct comprehensive omics profiling of cardiovascular disease patient cohorts from high-altitude to understand their unique cardiovascular adaptations and disease mechanisms. Additionally, this project also aims to characterize population-specific metabolic remodeling by untargeted lipidomic profiling. This project established high-altitude cardiovascular disease patient cohorts for understanding the complex interplay between evolutionary adaptation, environmental exposure, and metabolic remodeling in high-altitude environments. This project also provided mechanistic insights into how genetic and metabolic factors interact to influence cardiovascular health in extreme environmental conditions.

Results found

Linked to

	Label	Description
	SA540391 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540405 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540426 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540410 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540396 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540429 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540423 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SA540417 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project
	SU004751 Subject (Entity type)	A subject produced as part of the PR002881 project
	SA540388 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002881 project