Description:Mutations in the DJ-1 gene cause rare forms of autosomal recessive Parkinson's disease in humans, and increased levels of DJ-1 protein are often found in cancers. Thus, understanding the precise function of DJ-1 is of broad interest. We hypothesized that analyzing differences in metabolites between organisms with and without DJ-1 may lead to clues about the protein's function. Here, we present the results of our ongoing studies using multiple different model organisms.