PR002905 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M85G21

Description:This study evaluates the impact of PFOA exposure on the metabolome and immune response to SARS-2 using a ferret model. Ferrets were separated into control or PFOA-exposed groups and challenged with SARS-2. Longitudinal analyses encompassing clinical assessments, serological profiling, histopathology, and nuclear magnetic resonance (NMR) metabolomics revealed significant metabolic and immunological perturbations. We found that PFOA-induced metabolic changes were more prominent and sustained than those driven by infection. PFOA exposure was also associated with impaired immune function, as evidenced by decreased serum IgG levels, increased viral loads, and prolonged peak infectivity. These findings underscore the intensified effects of PFOA on host metabolism and immunity during infectious diseases.

Results found

Linked to

	Label	Description
	SU004788 Subject (Entity type)	A subject produced as part of the PR002905 project
	ST004607 SupplementaryData.zip File (Entity type)	A 3.64 GB file from Metabolomics produced from OBI:0000623 as part of the PR002905 project
	ST004607 Rawdata.zip File (Entity type)	A 113 MB file from Metabolomics produced from OBI:0000623 as part of the PR002905 project
	SA546116 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546180 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546187 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546165 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546203 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546100 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project
	SA546213 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002905 project

SU004788

Subject (Entity type)

A subject produced as part of the PR002905 project

ST004607 SupplementaryData.zip

File (Entity type)

A 3.64 GB file from Metabolomics produced from OBI:0000623 as part of the PR002905 project

ST004607 Rawdata.zip

File (Entity type)

A 113 MB file from Metabolomics produced from OBI:0000623 as part of the PR002905 project

SA546116

Biosample (Entity type)