PR002792 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8RV8C

Description:Altered microglial lipid metabolism is heavily implicated in Alzheimer’s disease (AD) and ageing. Recently, protocols were developed to generate human induced pluripotent stem cell-derived microglia-like cells (iMGL) to study microglial function in vitro, including embryoid body-based methods and transcription factor-dependent (iTF) approaches. Here, we performed comparative lipidomics on iMGL from these methods and report major differences in multiple lipid classes including triglycerides (TG), a storage form of fatty acids implicated in microglial reactivity. We compared the lipid composition of iPSC-derived microglia generated using a classical EB-based method and an iTF-based method.

Results found

Linked to

	Label	Description
	SA522432 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522579 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522474 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522458 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522394 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522424 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522448 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522515 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522439 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project
	SA522526 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002792 project