Description:In this pilot study, we performed global untargeted salivary metabolomics. We focused on salivary metabolomics as oral mucosa is the initial interface between the triggering antigens and the host mucosal immune system,9 saliva is rich yet understudied biofluid, and saliva can be collected safely, rapidly, and non-invasively (compared to esophageal and plasma samples) making it uniquely suited for testing pediatric populations.10 Our primary aim was to gain novel insights into the upstream metabolomic alterations in pediatric EoE by profiling salivary metabolome in children with EoE, and our secondary aim was to assess the translational potential of salivary metabolites.