PR002674 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M80Z6T

Description:This project aims to develop and validate a blood-based biomarker model to identify individuals at elevated risk of asthma exacerbations. Global metabolomics highlighted steroid, sphingolipid, and microbiome-linked metabolic pathways as associated with asthma status and exacerbation risk. Targeted quantification showed that sphingolipid-to-steroid ratios were strongly and consistently associated with 5‑year risk of exacerbation. Derived a simple predictive model based on 21 sphingolipid-to-steroid ratios that replicated across cohorts and outperformed current clinical measures (discovery AUC = 0.90; replication AUC = 0.89). These findings underscore the value of metabolomic profiling to develop a practical, cost-effective clinical assay for asthma exacerbation risk that may improve patient care.

Results found

Linked to

	Label	Description
	SA487804 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA488042 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA488674 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA488802 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA489720 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA488607 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA487906 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA489851 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA489439 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project
	SA488722 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002674 project