PR002991 (Project)

Dcc Asset:

MW submission packet 20260611.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M82855

Description:Secretory PLA2 exhibits tissue-specific expression patterns for each isoenzyme and displays specific selectivity toward its substrate, phospholipids. Regarding the association between sPLA2 and psoriasis, it has been reported that PLA2G2D in dendritic cells suppresses excessive Th17-type immune responses by generating omega-3 fatty acids within lymphoid tissues, thereby suppressing psoriasis, whereas PLA2G2F in epidermal keratinocytes generates lysolipids, promoting epidermal thickening and exacerbating psoriasis. Based on these findings, it is anticipated that other sPLA2 isoenzymes expressed in the skin and immune tissues also exert some influence on the pathogenesis of psoriasis. Recent studies have shown that pathological findings associated with psoriasis are attenuated in PLA2G12A knockout mice. We therefore examined changes in lipid composition during disease development using lymph nodes in which PLA2G12A is expressed. Our results revealed that, compared to wild-type mice, the production of specific lysophospholipids is reduced in the knockout mice.

Results found

Linked to

	Label	Description
	SU004902 Subject (Entity type)	A subject produced as part of the PR002991 project
	ST004719 2 Rawfiles.zip File (Entity type)	A 327 KB file from Metabolomics produced from OBI:0003097 as part of the PR002991 project
	ST004719 1 Rawfiles.zip File (Entity type)	A 2.92 MB file from Metabolomics produced from OBI:0003097 as part of the PR002991 project
	SA556779 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556782 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556787 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556774 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556785 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556778 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project
	SA556783 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002991 project