PR002240 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8325D

Description:Regulatory T cells (Tregs) are characterized by stable FOXP3 expression and controlling immune response by suppressive activity. Unique metabolic properties of Tregs are shown such as reduced glycolysis and increased oxidative phosphorylation. We have combined transcriptomics, metabolomics and lipidomics to dissect metabolic dynamics of Tregs upon activation. Combined metabolomic and lipidomic analysis showed that freshly isolated Tregs have unique metabolomic property, on the other hand, activated Tregs have unique lipidomic property. Interestingly, activated Tregs contained omega-3 polyunsaturated fatty acids (PUFA) enriched diglycerides and triglycerides.

Results found

Linked to

	Label	Description
	SA393431 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393436 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393438 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393434 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393430 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393433 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SU003757 Subject (Entity type)	A subject produced as part of the PR002240 project
	SA393441 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393440 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project
	SA393437 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002240 project