Description:In this study, we assessed the impact of myeloid cells on the levels of circulating metabolites in the plasma of mice bearing tumors. To do so, murine pancreatic ductal adenocarcinoma (PDAC) cells were implanted into C57Bl6J CD11b-DTR host animals. Myeloid cells were then ablated with 25 ng/g diptheria toxin (DT). Serum from DT treated mice was collected for analysis. Additionally, serum was collected from PDAC bearing mice that were vehicle treated. This data allows for identification of how myeloid cells in tumor bearing mice contribute to levels of circulating metabolites.