PR001414 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8Z42Q

Description:We have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Metabolomic landscape and glucose flux in control versus AD were assessed. Additionally, their response to PKM2 modulation (shikonin 10 µM or PKM2 overexpression) and hypoxia (CoDo treatment) were assessed.

Results found

Linked to

	Label	Description
	SA211855 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211834 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211847 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211843 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211872 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211845 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211875 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211883 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211846 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project
	SA211869 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001414 project