SAA1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:6288, HGNC:10513, MIM:104750, NM_000331, NM_001178006, NM_199161, NP_000322, NP_001171477, NP_954630, PIG4, SAA, SAA1, SAA2, TP53I4, serum amyloid A1

Id:ENSG00000288411

Description:serum amyloid A1 [Source:HGNC Symbol;Acc:HGNC:10513]

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Jul 2020]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SAA1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SAA1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SAA1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SAA1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SAA1.

Results found

Linked to

	Label	Description
	Nephropathy Phenotype (Entity type)	A nonspecific term referring to disease or damage of the kidneys.
	Malnutrition Phenotype (Entity type)	A deficiency in the intake of energy and nutrients.
	Acute kidney injury Phenotype (Entity type)	Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum crea...
	Chronic kidney disease Phenotype (Entity type)	Functional anomaly of the kidney persisting for at least three months.

Nephropathy

Phenotype (Entity type)

A nonspecific term referring to disease or damage of the kidneys.

Malnutrition

Phenotype (Entity type)

A deficiency in the intake of energy and nutrients.

Acute kidney injury

Phenotype (Entity type)

Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum crea...

Chronic kidney disease

Phenotype (Entity type)

Functional anomaly of the kidney persisting for at least three months.

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.