TGM1 (Gene)

Organism:

Homo sapiens

Synonyms:ARCI1, ENTREZ:7051, HGNC:11777, ICR2, KTG, LI, LI1, MIM:190195, NM_000359, NP_000350, TGASE, TGK, TGM1, transglutaminase 1

Id:ENSG00000285348

Description:transglutaminase 1 [Source:HGNC Symbol;Acc:HGNC:11777]

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TGM1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TGM1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TGM1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TGM1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TGM1.

Results found

Linked to

	Label	Description
	Alopecia Phenotype (Entity type)	A noncongenital process of hair loss, which may progress to partial or complete baldness.
	Sepsis Phenotype (Entity type)	Systemic inflammatory response to infection.

Alopecia

Phenotype (Entity type)

A noncongenital process of hair loss, which may progress to partial or complete baldness.

Sepsis

Phenotype (Entity type)

Systemic inflammatory response to infection.

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CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.