TOMT (Gene)

Entrez:120356740

Description:transmembrane O-methyltransferase

This gene encodes a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. Readthrough transcription is observed across this gene and the adjacent leucine-rich repeat containing 51 gene. A third locus (GeneID:220074) is defined to represent the readthrough transcripts. [provided by RefSeq, Feb 2021]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TOMT's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TOMT.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TOMT.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TOMT.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TOMT.

Results found

Linked to

	Label	Description
	GSE216988 GSE216989 decitabine 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE195663 cisplatin 7 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 14 v 12 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE186816 HTRA1 overexpression ARPE-19 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE218580 1 V 0 FENTANYL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE174745 dopamine neuron 1 v 5 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE156761 dopamine neuron 0 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 14 V 12 TEMOZOLOMIDE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE211151 1 V 0 PROGESTERONE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE111247 temozolomide LN-308 14 v 10 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE216988 GSE216989 decitabine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE195663 cisplatin 7 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 14 v 12 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE186816 HTRA1 overexpression ARPE-19 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE218580 1 V 0 FENTANYL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE174745 dopamine neuron 1 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE156761 dopamine neuron 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 14 V 12 TEMOZOLOMIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE211151 1 V 0 PROGESTERONE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE111247 temozolomide LN-308 14 v 10 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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