PRTN3 (Gene)

Organism:

Homo sapiens

Synonyms:ACPA, AGP7, C-ANCA, CANCA, ENTREZ:5657, HGNC:9495, MBN, MBT, MIM:177020, NM_002777, NP-4, NP4, NP_002768, P29, PR-3, PR3, PRTN3, XM_011528136, XP_011526438, proteinase 3

Id:ENSG00000277804

Description:proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]

Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Located in azurophil granule lumen; cytosol; and plasma membrane raft. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PRTN3's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PRTN3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PRTN3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PRTN3.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PRTN3.

Results found

Linked to

	Label	Description
	Hypertension Phenotype (Entity type)	The presence of chronic increased pressure in the systemic arterial system.
	Autoimmunity Phenotype (Entity type)	The occurrence of an immune reaction against the organism's own cells or tissues.
	Arthralgia Phenotype (Entity type)	Joint pain.
	Retinopathy Phenotype (Entity type)	Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wid...
	Pancreatitis Phenotype (Entity type)	The presence of inflammation in the pancreas.
	Meningitis Phenotype (Entity type)	Inflammation of the meninges.
	Chronic pulmonary obstruction Phenotype (Entity type)	An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inf...

Hypertension

Phenotype (Entity type)

The presence of chronic increased pressure in the systemic arterial system.

Autoimmunity

Phenotype (Entity type)

The occurrence of an immune reaction against the organism's own cells or tissues.

Arthralgia

Phenotype (Entity type)

Joint pain.

Retinopathy

Phenotype (Entity type)

Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wid...

Pancreatitis

Phenotype (Entity type)

The presence of inflammation in the pancreas.

Meningitis

Phenotype (Entity type)

Inflammation of the meninges.

Chronic pulmonary obstruction

Phenotype (Entity type)

An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inf...

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.