ELANE (Gene)

Organism:

Homo sapiens

Synonyms:ELA2, ELANE, ENTREZ:1991, GE, HGNC:3309, HLE, HNE, MIM:130130, NE, NM_001972, NP_001963, PMN-E, SCN1, XM_011527775, XM_011527776, XP_011526077, XP_011526078, elastase, neutrophil expressed

Id:ENSG00000277571

Description:elastase, neutrophil expressed [Source:HGNC Symbol;Acc:HGNC:3309]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ELANE's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ELANE.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ELANE.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ELANE.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ELANE.

Results found

Linked to

	Label	Description
	Autoimmunity Phenotype (Entity type)	The occurrence of an immune reaction against the organism's own cells or tissues.
	Sepsis Phenotype (Entity type)	Systemic inflammatory response to infection.
	Colitis Phenotype (Entity type)	Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...
	Periodontitis Phenotype (Entity type)	Inflammation of the periodontium.
	Gingivitis Phenotype (Entity type)	Inflammation of the gingiva.
	Enterocolitis Phenotype (Entity type)	An inflammation of the colon and small intestine. However, most conditions are either categorized as...

Autoimmunity

Phenotype (Entity type)

The occurrence of an immune reaction against the organism's own cells or tissues.

Sepsis

Phenotype (Entity type)

Systemic inflammatory response to infection.

Colitis

Phenotype (Entity type)

Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the ...

Periodontitis

Phenotype (Entity type)

Inflammation of the periodontium.

Gingivitis

Phenotype (Entity type)

Inflammation of the gingiva.

Enterocolitis

Phenotype (Entity type)

An inflammation of the colon and small intestine. However, most conditions are either categorized as...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.