Synonyms:CLR19.4, ENTREZ:199713, HGNC:22947, HYDM, MIM:609661, NALP7, NLR family pyrin domain containing 7, NLRP7, NM_001127255, NM_139176, NM_206828, NOD12, NP_001120727, NP_631915, NP_996611, PAN7, PYPAF3, XM_006723075, XM_006723076, XM_011526596, XM_011526599, XM_011526601, XP_006723138, XP_006723139, XP_011524898, XP_011524901, XP_011524903, XR_935761
Id:ENSG00000276804
Description:NLR family pyrin domain containing 7 [Source:HGNC Symbol;Acc:HGNC:22947]
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
